TRANCE / TNFSF11 / RANKL ELISA Kit, Mouse

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse TRANCE. The Mouse TRANCE/TNFSF11/RANKL ELISA is for research use only. Not for diagnostic or therapeutic procedures. TNF-related activation-induced cytokine (TRANCE), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), receptor activator of nuclear factor kappa-B ligand (RANKL), is a member of the TNF superfamily. Cells known to express TRANCE include osteoblasts, CD4+ and CD8+ T cells, megakaryocytes, bronchial and intestinal epithelium and so on. TRANCE appears to play a central role in both immune response and bone morphogenesis. During bone development and remodeling, TRANCE expression by osteoblasts in conjunction with M-CSF induces osteoclast formation and activation, resulting in bone resorption. This allows for subsequent bone deposition and remodeling. TRANCE also plays a role in pathological osteoporosis. Its inappropriate expression by activated lymphocytes and osteoblasts results in excessive joint and bone resorption vs. deposition. Overproduction of TRANCE is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

4.23 pg/ml

83 % - 116 %

n.d. - 102.7 pg/ml

6.0 % - 8.9 %