CXCL10/IP-10 ELISA Kit, Mouse

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse IP-10. The Mouse CXCL10/IP-10 ELISA is for research use only. Not for diagnostic or therapeutic procedures. C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10), is an 8.7 kDa protein that belongs to the CXC chemokine family. IP-10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. IP-10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. IP-10 shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer’s disease. Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

19.03 pg/ml

71 % - 122 %

n.d. - 1367.9 pg/ml

2.2 % - 5.3 %