Insulin Degrading Enzyme (IDE) ELISA Kits Format 2 (human, mouse, rat, canine, rabbit)

INS, IDE

Insulin-degrading enzyme (abbreviated IDE), also known as insulysin or insulin protease, is a zinc-binding protease of the M16A metalloprotease subfamily known to cleave short polypeptides with variable sequences. IDE was first identified by its ability to degrade the B chain of insulin. IDE, which migrates at 110 kDa in gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF alpha, beta-endorphin and amyloid-beta (Abeta).

In vitro and in vivo studies have shown correlations between IDE activity levels, Abeta degradation, and Alzheimer’s disease. Mice engineered to lack both alleles of the IDE gene exhibit a 50% decrease in Abeta degradation, resulting in cerebral accumulation of Abeta. Studies of genetically inherited forms of Alzheimer’s show reduction in both IDE expression and catalytic activity among affected individuals.