Presenilin 2 Elisa Kit (human, mouse, rat, canine)

Manufacturer Fivephoton
Type Elisa-Kit
Specific against Human, Mouse, Rat, Canine
Amount 96T
Item no. PS2-ELISA
Eclass 6.1 32160605
Eclass 9.0 32160605
Poisonous Material
Sodium Azide (0.1%)
Sandwich ELISA format providing convenience, high sensitivity and selectivity
Highly sensitive; pg/ml detection
Affinity purified polyclonal capture antibody coated on plate. Separate HRP-conjuated detection antibody
Rapid colorimetric detection. 1 hr total incubation at 37C; 2 hr incubation at RT
Suitable for membrane extracts, cell lysates, tissue homogenates and other mediums
Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase protease complex. Vertebrates have two presenilin genes, called PSEN1 (located on chromosome 14 in humans) that encode Presenilin 1 (PS-1) and PSEN2 (on chromosome 1 in humans) that codes for presenilin 2 (PS-2). Both genes show conservation between species, with little difference between rat and human presenilins.
Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a larger N-terminal and a smaller C-terminal fragment, which together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation which causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.
Dominant mutations in the genes that encode presenilin proteins are the most common cause of familial early-onset Alzheimer's disease.
Separate ELISA kits are available for human, mouse, rat, rabbit and canine Presenilin 2.
Gamliel A, Teicher C, Michaelson DM, Pradier L, Hartmann T, Beyreuther K, Stein R. Increased expression of presenilin 2 inhibits protein synthesis. Molecular And Cellular Neurosciences 19: 111-124, 2002.

Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. The Journal of Biological Chemistry 272: 11006-11010, 1997.

Takahashi H, Mercken M, Nakazato Y, Noguchi K, Murayama M, Imahori K, Takashima A. Cloning of cDNA and expression of the gene encoding rat presenilin-2. Gene 197: 383-387, 1997.

Tanimukai H, Tsujio I, Hashimoto R, Kudo T, Kamino K, Shinozaki K, Takeda M. Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients. Clinica chimica acta international journal of clinical chemistry 283: 57-61, 1999.
Amount: 96T
Available: In stock
Listprice: €985.23
Price: €985.23

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