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BACE1 ELISA Kits (for human, mouse, rat, canine)

BACE1 ELISA Kits (for human, mouse, rat, canine)

Item no.	BACE1-ELISA
Manufacturer	Fivephoton
Amount	96 T
Category	Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding ELISA ELISA & Immunoassays ELISA Kits Immunoassay
Type	Elisa-Kit
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Dog (Canine, Canis lupus familiaris)
Citations	Schubert C. Alzheimer disease: BACE1 branches out. Nature Medicine 12: 1123, 2006. Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, Wilson CG, Yan R. BACE1 deficiency causes altered neuronal activity and neurodegeneration. Journal of Neuroscience 30: 8819-8829, 2010. Kang EL, Cameron AN, Piazza F, Walker KR, Tesco G. Ubiquitin Regulates GGA3-mediated Degradation of BACE1. The Journal of Biological Chemistry 285: 24108-24119, 2010. Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S. BACE1 interacts with nicastrin. Biochemical and Biophysical Research Communications 293: 1228-1232, 2002. Fleck D, Garratt AN, Haass C, Willem M. BACE1 Dependent Neuregulin Proteolysis. Current Alzheimer Research. Parsons RB, Farrant JK, Price GC, Subramaniam D, Austen BM. Regulation of the lipidation of beta-secretase by statins. Biochemical Society Transactions 35: 577-582, 2007. Cole DC, Manas ES, Stock JR, Condon JS, Jennings LD, Aulabaugh A, Chopra R, Cowling R, Ellingboe JW, Fan KY, Harrison BL, Hu Y, Jacobsen S, Jin G, Lin L, Lovering FE, Malamas MS, Stahl ML, Strand J, Sukhdeo MN, Svenson K, Turner MJ, Wagner E, Wu J, Zhou P, Bard J. Acylguanidines as small-molecule beta-secretase inhibitors. Journal of Medicinal Chemistry 49: 6158-6161, 2006. John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. Human beta-secretase (BACE) and BACE inhibitors. Journal of Medicinal Chemistry 46: 4625-4630, 2003.
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Hazard information	Sodium Azide (0.1%)
Available
Poisonous Material	Sodium Azide (0.1%)
Background	beta-Secretase (BACE1) is an aspartyl protease involved in the cleavage of amyloid precursor protein (APP). BACE1 is a transmembrane protein with two active site aspartate residues in its extracellular protein domain. BACE1 may operate functionally as a dimer. Generation of amyloid-beta peptide requires two sequential cleavages of amyloid precursor protein (APP). Extracellular cleavage of APP by BACE1 creates a soluble extracellular fragment and a cell membrane-bound fragment. Cleavage of a membrane bound fragment by gamma-secretase releases the intracellular domain of APP and yields amyloid-beta peptide. Levels of BACE1enzymatic activity appear to be elevated in age related, late-onset Alzheimer's potentially suggesting a gene regulatory mechanism.
Highlights	Pre-configured sandwich ELISA format providing convenience and high sensitivity. Strip plate configuration allowing separate use and storage of plate sections. Suitable for serum, plasma, cell and tissue lysates, cell culture medium Affinity purified polyclonal capture antibody coated on plate. Separate HRP-conjugated capture antibody. Rapid colorimetric detection. 1 hr total incubation (with plate and HRP antibody) at 37C; 2 hr incubation at RT. Separate kits available for human, mouse, rat, canine and rabbit. Highly sensitive pg/ml detection.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 96 T

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Delivery expected until 10/2/2025

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