Rat Kallikrein-6 (KLK6) ELISA Kit

Manufacturer Fivephoton
Category Products / ELISA
Type Elisa-Kit
Specific against Rat
Amount 96T
ArtNr rKLK6-Biotin
Eclass 6.1 32160605
Eclass 9.0 32160605
Available
Highlights
Fully pre-configured ELISA kit in sandwich assay format.
Standard peptide concentration: 48ng/ml
Dynamic Assay Range: 200pg/ml - 40ng/ml. Sensitivity: 0.145ng/ml.
Rapid ELISA Protocol: Requires one 60 min incubation period at 37C.
Samples are mixed with the provided biotinylated detection antibody and provided streptavidin-HRP prior to addition to plate.
Available in 48T and 96T formats.
Background
Kallikrein-6 is a protein with serine protease activity that is detected with grey matter neurons and colocalizes with pathological inclusions. Kallikreins have many known functions; they are associated with carcinogenisis and are thought to be disease biomarkers. Kallikrein-6 has been found to cleave amyloid precursor protein as well as myelin basic protein, gelatin, casein, and many extracellular matrix proteins. Kallikrein-6 also cleaves alpha-synuclein, preventing polymerization.
References
Ashby EL, Kehoe PG, Love S. Kallikrein-related peptidase 6 in Alzheimer’s disease and vascular dementia. Brain Research 1363: 1-10, 2010.

Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV. The new human kallikrein gene family: implications in carcinogenesis. Trends in endocrinology and metabolism TEM 11: 54-60, 2000.

Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP. Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. Biochemical and Biophysical Research Communications307: 948-955, 2003.

Menendez-Gonzalez M, Castro-Santos P, Suarez A, Calatayud MT, Perez-Pinera P, Martinez M, Ribacoba R, Gutierrez C. Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer’s disease. Journal of Alzheimers disease JAD 14: 59-67, 2008.

Ogawa K, Yamada T, Tsujioka Y, Taguchi J, Takahashi M, Tsuboi Y, Fujino Y, Nakajima M, Yamamoto T, Akatsu H, Mitsui S, Yamaguchi N. Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer’s disease and Parkinson's disease.Psychiatry and Clinical Neurosciences 54: 419-426, 2000.

Okui A, Kominami K, Uemura H, Mitsui S, Yamaguchi N. Characterization of a brain-related serine protease, neurosin (human kaillikrein 6), in human cerebrospinal fluid. NeuroReport 12: 1345-1350, 2001.

Shan SJC, Scorilas A, Katsaros D, Diamandis EP. Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects. British Journal of Cancer 96: 362-372, 2007.
Amount: 96T
Available: In stock
Listprice: €817.80
Discount: -10%
Price: €736.02
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