APP Antibody (Phospho-Tyr757), pAb, Rabbit

USA

GenScript Rabbit Anti-APP (Phospho-Tyr757) Polyclonal Antibody can specifically detect human APP (Phospho-Tyr757) only when phosphorylated at threonine 757.

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is found as three main isoforms, APP695, APP751, and APP770. APP can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid, which is the main component of senile plaque in patient brains inflicted with Alzheimer's disease. Phosphorylation of APP at Tyr757 and 762 is important for MAPK8IP1, APBA1, shcA/shcC, and DAB1 binding. Binding interactions regulated by phosphorylation determine the localization and the function of APP. For these reasons, Anti-APP (Phospho-Tyr757) antibody can be useful in the tracing of the processing, distribution and interactions of APP. GenScript, Rabbit Anti-APP (Phospho-Tyr757) Polyclonal Antibody, is developed in rabbit using a synthetic phosphopeptide derived from human APP around the phosphorylation site of tyrosine 757 (N-G-YP-E-N), KLH-coupled.

The antibody is purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide and cross-adsorbed with the corresponding non-phosphopeptide.