PEN2 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-PEN2 Polyclonal Antibody can be used to detect human PEN2. It is predicted to react with mouse, rat and bovine PEN2 according to sequence homology.

Presenilin enhancer protein 2 (PEN2) is a 101-amino acid protein that traverses the membrane twice and it is the regulatory component of the multimeric gamma-secretase complex which also consists of presenilin, APH-1 and Nicastrin. The gamma-secretase complex catalyzes the cleavage of a number of integral membrane proteins including beta-amyloid precursor protein (APP), Notch protein, Erb4 and E-cadherin. The gamma-secretase complex cleaves the APP yielding amyloid beta peptide, which is the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. In addition, PEN2 is required for end proteolysis of presenilin and activation of the gamma-secretase. GenScript, Rabbit Anti-PEN2 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide derived from human PEN2.

Immunoaffinity chromatography