APH1 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-APH1 Polyclonal Antibody can detect endogenous levels of human and mouse APH1a.

Anterior Pharynx-Defective 1 (APH1), in addition to presenilin, PEN2, and Nicastrin forms the gamma-secretase protein complex. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. The gamma-secretase complex can cleave the beta-amyloid (A4) precursor protein and yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Three mammalian homologues of APH1 have been identified: APH1a, APH1b, and APH1c, of which APH1a is more abundantly expressed than APH1b in human tissue samples. In addition, two isoforms of APH1a can be generated from alternative splicing of APH-1a, APH1a long form (APH1aL) and APH1a short form (APH1aS) that diverge at the C-terminus. APH1a is the major mammalian APH1 isoform required for Notch signaling during embryogenesis and the major APH1 isoform required for the assembly of the gamma-secretase complexes and APP processing. GenScript, Rabbit Anti-APH1 Polyclonal Antibody, is developed in rabbit using a synthetic peptide, RRQEDSRVMVYSALRIPPED, corresponding to amino acids 246-265 of the C-terminus of human APH1a. GenScript Rabbit Anti-APH1 Polyclonal Antibody is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as a 40 ug aliquot at a concentration of 0.5 mg/ml.

Immunoaffinity chromatography