PKCbeta2 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-PKCβ, 2 Polyclonal Antibody detects endogenous levels of total PKCβ, 2 protein. No cross-reactivity to other PKC isoforms is detected.

Protein kinase C ('PKC', EC 2.7.11.13) is a cyclic nucleotide-independent enzyme that phosphorylates serine and threonine residues in many target proteins. The PKC family has been divided into three groups differing in the enzymes' cofactor requirements: conventional (c)PKC isoforms (comprising alpha, betaI (also known as beta1), betaII (also known as beta2) and gamma), that require diacylglycerol (DAG), Ca2+, and phospholipid for activation, novel (n)PKC isoforms (comprising delta, epsilon, eta (also known as PKC-L), theta and u (the mouse homolog of human PKCu, also known as PKD)) that require DAG but not Ca2+, and atypical (a)PKC isoforms, namely zeta, iota and lambda (the mouse homolog of human PKC iota) that require neither Ca2+ nor DAG. A new PKC member has recently been discovered and is referred to as PKCny. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKCbeta1 and PKCbeta2 isoforms are encoded by the same gene but diverge at the C-terminal (V5) region as a result of differential mRNA splicing. The PKCbeta1/beta2 isoenzymes appear to be widely expressed. GenScript, Rabbit Anti-PKCbeta2 Polyclonal Antibody, is developed in rabbit hosts using a synthetic peptide (KLH-coupled) derived from the C-terminal variable (V5) region of human PKCbeta2.

Immunoaffinity chromatography