CCR3 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-CCR3 Polyclonal Antibody detects human CCR3 protein. It has not yet been tested with other species.

CCR3 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13). In addition, it has been reported to bind RANTES, MCP-3 and MCP-4. CCR3 has been shown to exist in blood, brain, lung, bone marrow, kidney, liver, lymph node, placenta, skin, spleen, thymus, thyroid, uterus, and vessel. The agonists for CXCR3 (IP-10, mig, and I-TAC) act as antagonists for CCR3 by competing for the binding of eotaxin to CCR3. CCR3 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. Meanwhile, CCR3 can also serve as a receptor for HIV-1 cell entry. GenScript, Rabbit Anti-CCR3 Polyclonal Antibody, is developed in rabbit hosts using a KLH-coupled synthetic peptide derived from N-terminal extracellular domain of human CCR3.

Immunoaffinity chromatography