PCNA Antibody, mAb, Mouse

USA

GenScript Mouse Anti-PCNA Monoclonal Antibody can detect endogenous level of human PCNA. It has not yet been tested with other species.

The proliferating cell nuclear antigen (PCNA) is a 36kD nuclear protein associated with the cell cycle. PCNA was initially identified as a nuclear antigen in proliferating cells and was subsequently described as a subunit for DNA polymerase delta. PCNA protein levels peak during the S-phase of the cell cycle, at which time it forms a complex with the p21 inhibitor. PCNA is almost undetectable in other phases of the cycle. Because of its unique expression, PCNA has been extensively used in studies associating the prognosis of tumor progression and neoplastic proliferation. GenScript, Mouse Anti-PCNA Monoclonal Antibody, is developed in mouse using recombinant human PCNA protein. GenScript Mouse Anti-PCNA is highly purified from mouse ascites by protein A chromatography and is supplied as 40 ug aliquot.

Recombinant PCNA protein

Reconstitute the lyophilized Mouse Anti-PCNA Monoclonal Antibody (40 μ, g) with 80 μ, l deionized water to the final concentration of 0.5 mg/ml.