beta-Catenin Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-β, -Catenin Polyclonal Antibody detects endogenous levels of human β, -catenin protein. Sequence homology predicts that it will also react with rat β, -catenin.

beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs play a role in mediating the adhesion between cells, signaling the presence of neighboring cells, and anchoring the actin cytoskeleton. In serving these roles, AJs also regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. GenScript, Rabbit Anti-beta-Catenin Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide within residues 700-750 of human beta-Catenin protein (Swiss Prot: P35222).

Immunoaffinity chromatography

85 kD