TrkA Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-TrkA Polyclonal Antibody detects human TrkA protein. It is predicted to react with mouse and rat according to sequence homology.

TrkA is one member of Trk receptor tyrosine kinase family that consists of TrkA, TrkB and TrkC. TrkA plays an important role in proliferation and maturation of the nervous system. TrkA phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. TrkA kinase activity depends on phosphorylation of residues Tyr674/675 within catalytic domain. TrkA signals growth arrest and differentiation of cells originating from the neural crest, and can serve as a prognostic marker in neuroblastomas. GenScript, Rabbit Anti-TrkA Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human TrkA (Swiss Prot: P04629).

Immunoaffinity chromatography

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.