Histone H2B Antibody (Acetyl-K20), pAb, Rabbit

USA

GenScript Rabbit Anti-Histone H2B (Acetyl-K20) Polyclonal Antibody detects endogenous levels of human and mouse Histone H2B only when acetylated at Lys20. It is predicted to react with rat species according to sequence homology. Positive Control: Hela, HepG2 and mouse brain.

Histone H2B is a core component of nucleosome that facilitates nucleosome wrapping and DNA compacting into chromatin. This limits the accessibility of DNA to the cellular machineries for which DNA is required as a template. Histones thereby play a central role in transcription regulation, DNA repair and replication as well as chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, of which the process is called the histone code, and nucleosome remodeling. GenScript, Rabbit Anti-Histone H2B (Acetyl-K20) Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic acetylpeptide corresponding to residues surrounding Lys20 of human Histone H2B. (Swiss Prot: Q5QNW6).

Immunoaffinity chromatography using acetylpeptide, cross-adsorbed with the corresponding non-acetylpeptide