mGluR5 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-mGluR5 Polyclonal Antibody detects endogenous levels of human mGluR5. It is predicted to react with mouse and rat mGluR5 protein according to sequence homology. Positive Control: Ramos

Metabotropic glutamate receptor 5 (mGluR5) is one member of G-protein coupled receptor 3 family. The activity of mGluR5 receptor is mediated by a G-protein that activates phosphatidylinositol-calcium second messenger system and generates calcium-activated chloride current. mGluR5 plays a critical role in the modulation of synaptic plasticity and behavioral responses to multiple substances of abuse. The expression of mGluR5 is widely distributed in brain regions relating to memory, such as the hippocampus. mGluR5 regulates phospholipid hydrolysis in developing cortical neurons through the activation of PLC-beta1. The receptor regulates glutamatergic transmission in a variety of brain regions, particularly those thought to participate in reward-related behaviors. Its activation by the group I mGluR agonist (RS)-3, 5-dihydroxyphenylglycine (DHPG) can induce long term depression (DHPG-LTD) of glutamatergic synaptic transmission. GenScript, Rabbit Anti-mGluR5 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human mGluR5 (Swiss Prot: P41594).

Immunoaffinity chromatography

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.