GAD65 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-GAD65 Polyclonal Antibody detects endogenous levels of human GAD65. Positive Control: SH-SY5Y.

Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain. There are two isoforms of GAD, GAD65 (GAD2) and GAD67 (GAD1) (65 and 67 kDa, respectively) encoded by two different genes. With 64% amino acid identity, the two isoforms have distinct intraneuronal distribution in the brain. The highest degree of diversity appears to be located at the N-terminus. Primarily found in nerve terminals, GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. GAD67 is thought to be primarily located in the nerve cell body and has been identified as a major autoantigen in type 1 diabetes. GenScript, Rabbit Anti-GAD65 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human GAD65 (Swiss Prot: Q05329).

Immunoaffinity chromatography

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.