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SMURF 2 Antibody, pAb, Rabbit

SMURF 2 Antibody, pAb, Rabbit

Item no.	A01654-40
Manufacturer	GenScript
Amount	40 ug
Category	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Autophagy Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Antibody Polyclonal
Applications	WB, other
Specific against	Human (Homo sapiens), other
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	A01654-SMURF_2_Antibody_pAb_Rabbit,Smad specific E3 ubiquitin ligase 2 Antibody, pAb, Rabbit,
Similar products	SMURF
Available
Specificity	Human. Reactivity to other species is not tested yet.
Country of Origin	USA
Storage Conditions	The antibody is stable in lyophilized form if stored at -20C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8C. For long term storage, aliquot and store at -20C or below. Avoid repeated freezing and thawing cycles.
Manufacturer - Specificity	GenScript SMURF 2 Antibody, pAb, Rabbit, detects human SMURF 2 protein. Predicted to react with mouse SMURF 2 protein according to sequence homology.
Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Description	SMURF 2 (specific E3 ubiquitin protein ligase 2), also known as SMAD, is an ubiquitin E3 ligase located mainly at nucleus. SMURF 2 binds to SMAD7 exports and recruits to the activated transforming growth factor-beta receptor (TGFBR). It causes degradation of receptors and of SMAD7 via proteasomal and lysosomal pathways. In the presence of RNF11, SMURF 2 ubiquitinates AMSH leading to its degradation by the 26S proteasome. SMURF 2 upregulation is induced by telomere attrition in human fibroblasts and its upregulation can trigger the senescence phenotype. SMURF 2 activates senescence through the RB and p53 pathways. GenScript SMURF 2 Antibody, pAb, Rabbit, is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human SMURF 2 protein (Swiss Prot: Q9HAU4).
Immunogen	KLH-coupled synthetic peptide from N-terminal of human SMURF 2 (Swiss Prot: Q9HAU4).
Purification Method	Immunoaffinity chromatography
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 40 ug

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Delivery expected until 11/13/2025

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