BIN1 Antibody, pAb, Rabbit

USA

GenScript BIN1 Antibody, pAb, Rabbit, detects endogenous levels of human BIN1 protein. Predicted to react with mouse and rat BIN1 protein according to sequence homology. Positive Control: Hela

Bin1 (Box-dependent myc interacting protein 1) is probably a tumor suppressor which interacts with and inhibits the oncogenic activity of the myc oncoprotein. It may be involved in regulation of synaptic vesicle endocytosis. The loss of Bin1 may contribute to growth deregulation in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 interacts with HCV NS5A through its SH3 domain. Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM). BIN1 alternative splice give rises to many isoforms. GenScript BIN1 Antibody, pAb, Rabbit, is developed in rabbit using a KLH-coupled synthetic peptide from N-terminus of human BIN1 (Swiss Prot: O00499).

Immunoaffinity chromatography