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Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)

Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)

Item no.	RP10108
Manufacturer	GenScript
Amount	1 mg
Category	Oncology Food Safety Antibiotics By Cell Type Hematology Leukemia Lymphoma Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	> 95%
Sequence	SFPWMESDVT ; {SER}{PHE}{PRO}{TRP}{MET}{GLU}{SER}{ASP}{VAL}{THR}
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP10108-Prepro_TRH_160-169_Ps4, The precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. In a heterologous TSH expression assay, we found that prepro-TRH- (160-169) stimulated TSH beta gene promoter activity in a time- and dose-dependent manner, moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSH beta- directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocritic effects at the level of the genome.</td></tr><tr><th>Solubility</th><td colspan="7"> Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. </td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Before using, store the peptide in the DRY form at 0 - 5C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions. </td></tr>
Similar products	Prepro
Available
Country of Origin	USA
Storage Conditions	Before using, store the peptide in the DRY form at 0 - 5C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
Description	The precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. In a heterologous TSH expression assay, we found that prepro-TRH- (160-169) stimulated TSH beta gene promoter activity in a time- and dose-dependent manner, moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSH beta- directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocritic effects at the level of the genome.
Solubility	Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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