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[Sar1, Ile8]-Angiotensin II

[Sar1, Ile8]-Angiotensin II

Item no.	RP13720
Manufacturer	GenScript
Amount	5 mg
Category	Peptides & Proteins Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Peptides
Type	Peptides
Specific against	other
Purity	> 95%
Sequence	Sar-RVYIHPI ; {SAR}{ARG}{VAL}{TYR}{ILE}{HIS}{PRO}{ILE}
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP13720-Angiotensin_II_Sar1_Ile8, The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation. Our investigations found that the most potent competitive antagonist of angiotensin II-stimulated aldosterone production was the [Sar1, Ile8] derivative of angiotensin II. However, this peptide was also a partial agonist at concentrations required to inhibit the steroidogenic effect of angiotensin II on dog adrenal cells, and never reduced aldosterone production to basal levels. </td></tr><tr><th>Solubility</th><td colspan="7"> GenScript angiotensin II is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. </td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Storage at -20C. Keep tightly closed. </td></tr>
Similar products	[Sar1
Available
Country of Origin	USA
Storage Conditions	Storage at -20C. Keep tightly closed.
Description	The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation. Our investigations found that the most potent competitive antagonist of angiotensin II-stimulated aldosterone production was the [Sar1, Ile8] derivative of angiotensin II. However, this peptide was also a partial agonist at concentrations required to inhibit the steroidogenic effect of angiotensin II on dog adrenal cells, and never reduced aldosterone production to basal levels.
Solubility	GenScript angiotensin II is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.

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