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IL-8/CXCL8 (3-79aa), Human

IL-8/CXCL8 (3-79aa), Human

Item no.	Z02189-50
Manufacturer	GenScript
Amount	50 ug
Category	Oncology Food Safety Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Contaminants Cell Migration & Invasion Metals By Organ Breast Cancer Heart & Blood Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
Purity	The purity of recombinant, Human Interleukin-8 (IL-8), is greater than 95.0%, as determined by the following methods: (a) RP-HPLC analysis, (b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis
Sequence	The sequence of the first five N-terminal amino acids has been found to be Ala-Val-Leu-Pro-Arg.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02189_50-Interleukin_8_IL_8_3_79_Human,Interleukin-8 (IL-8), belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 (IL-8) levels are associated with the onset of a variety of disease states. Human Interleukin-8 (IL-8) (3-79), , produced in, E. coli , is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8,904 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 9,000 Da+/-10%, determined by reduced SDS-PAGE</td></tr><tr><th>Purity</th><td colspan="7"> The purity of recombinant, Human Interleukin-8 (IL-8), is greater than 95.0%, as determined by the following methods: (a) RP-HPLC analysis, (b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1ng/ug (1 IEU/ug) determined by LAL test.</td></tr><tr><th>Storage</th><td colspan="7"> Although lyophilized Recombinant, Human Interleukin-8 (IL-8) /77 can remain stable at room temperature for three weeks, it is best stored desiccated below -18C. After reconstitution, Recombinant Human Interleukin-8 (IL-8)/77 may be stored at 4C for up to seven days and below -18C for longer periods. For long-term storage it is recommended that a carrier protein (0.1% HSA or BSA) be added. Please avoid freeze-thaw cycles.</td></tr><tr><th>Specificity</th><td colspan="7"> GenScript rHuIL-8 /77 is fully biologically active when compared to standard. The ED50, as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells, is less than 2 ng/ml, corresponding to a specific activity of 5.0×105 IU/mg.</td></tr><tr><th>Formulation</th><td colspan="7"> The protein was lyophilized after extensive dialysis against PBS, pH7.4.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended that lyophilized GenScript rHuIL-8 /77 be reconstituted in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.</td></tr><tr><th>Sequence</th><td colspan="7"> The sequence of the first five N-terminal amino acids has been found to be Ala-Val-Leu-Pro-Arg.</td></tr>
Similar products	Interleukin-8
Available
Specificity	GenScript rHuIL-8 /77 is fully biologically active when compared to standard. The ED50, as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells, is less than 2 ng/ml, corresponding to a specific activity of 5.0x105 IU/mg.
Country of Origin	USA
Storage Conditions	Although lyophilized Recombinant, Human Interleukin-8 (IL-8) /77 can remain stable at room temperature for three weeks, it is best stored desiccated below -18C. After reconstitution, Recombinant Human Interleukin-8 (IL-8)/77 may be stored at 4C for up to seven days and below -18C for longer periods. For long-term storage it is recommended that a carrier protein (0.1% HSA or BSA) be added. Please avoid freeze-thaw cycles.
Molecular Weight	9, 000 Da+/-10%, determined by reduced SDS-PAGE
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	GenScript rHuIL-8 /77 is fully biologically active when compared to standard. The ED50, as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells, is less than 2 ng/ml, corresponding to a specific activity of 5.0x105 IU/mg.
Description	Interleukin-8 (IL-8), belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 (IL-8) levels are associated with the onset of a variety of disease states. Human Interleukin-8 (IL-8) (3-79), , produced in, E. coli , is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8, 904 Da.
Reconstitution	It is recommended that lyophilized GenScript rHuIL-8 /77 be reconstituted in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Formulation	The protein was lyophilized after extensive dialysis against PBS, pH7.4.
Endotoxin Level	Less than 0.1ng/ug (1 IEU/ug) determined by LAL test.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 9/11/2025

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