Kallikrein 6, Human

USA

-65

Kallikrein 6 (KLK-6) , also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis, and some have potential as novel cancer and other disease biomarkers. KLK-6 was originally characterized from the brain as an enzyme involved in the degradation of amyloid plaque protein (APP) and was thought to be a beta secretase. KLK-6 was shown to be elevated in the sera of patients with Alzheimer’s disease, Parkinson’s disease and in animal models of multiple sclerosis. Studies indicate KLK-6 may participate in the demyelination processes and progression of CNS inflammatory disease.
Recombinant Human Kallikrein 6 produced in CHO cells is a polypeptide chain containing 238 amino acids. A fully biologically active molecule, rhKLK6 has a molecular mass of 31 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.