VEGF R2/KDR Fc Chimera, Human

USA

-65

Vascular endothelial growth factor receptor 2 (VEGF R2) , also known as Kinase insert domain receptor (KDR) and Fetal Liver Kinase 1 (Flk-1), is a type III receptor tyrosine kinase which plays a critical role in angiogenesis. VEGFR-1 and VEGFR-2 are closely related receptor tyrosine kinases and have both common and specific ligands. VEGFR-1 is a kinase-impaired RTK whereas VEGFR-2 is a highly active kinase. Vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) as well as blood-vessel formation (angiogenesis) in the adult. In mammals, five VEGF ligands, which occur in several different splice variants and processed forms, have been identified so far. These ligands bind in an overlapping pattern to three receptor tyrosine kinases (RTKs), known as VEGF receptor-1, -2 and -3 (VEGFR1-3), as well as to co-receptors (here defined as VEGF-binding molecules that lack established VEGF-induced catalytic function), such as heparin sulphate proteoglycans (HSPGs) and neuropilins.
Recombinant Human VEGF R2/KDR produced in CHO cells is a polypeptide chain containing 978 amino acids. rhVEGFR2/KDR has a molecular mass of 150 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.