Prostaglandin F2-alpha receptor anti-Human

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (4 - 8 ug/ml) ICC (Optimal dilution to be determined by the researcher)

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha) which is known to be a potent luteolytic agent and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [1] Chen X. B. and Regan J. W. et al. Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy[2] Hebert R. L. Carmosino M. Saito O. Yang G. Jackson C. A. Qi Z. Breyer R. M. Natarajan C. Hata A. N. Zhang Y. Guan Y. and et al. Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct[3] Mandal A. K. Ray R. Zhang Z. Chowdhury B. Pattabiraman N. and Mukherjee A. B. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators[4] Scott G. Jacobs S. Leopardi S. Anthony F. A. Learn D. Malaviya R. and Pentland A. Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation[5] Sugino N. Karube-Harada A. Taketani T. Sakata A. and Nakamura Y. et al. Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation[6] Abramovitz M. Boie Y. Nguyen T. Rushmore T. H. Bayne M. A. Metters K. M. Slipetz D. M. Grygorczyk R. Cloning and expression of a cDNA for the human prostanoid FP receptor. [7] Kunapuli P. Lawson J. A. Hwang S. W. Adiyaman M. Khanapure S. P. Rokach J. G. A. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases. [8] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [9] Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. et al. The DNA sequence and biological annotation of human chromosome 1. [10] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.