RABBIT ANTI HUMAN ACTIN BETA (N-TERMINAL)

GWB-3ED638

Polyclonal IgGSpecies Cross Reactivity: Reacts with: Mouse RatN. B. Antibody reactivity and working conditions may vary between species.

Recognises Actin beta (known also as ACTB and Beta Actin) a 41. 7 kDa cytoskeletal protein. Actins are highly conserved proteins that are involved in cell motility structure and integrity and are ubiquitously expressed in all eukaryotic cells. Six different isoforms of Actin have been identified of these Actin beta is one of the three isoforms found in vertebrates. Defects in Actin beta are a cause of juvenile dystonia a condition that results in movement disorders due to disordered muscle tonicity abnormal posture development malformations and sensory hearing loss. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)

Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref. 15Involvement in diseaseDefects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction often leading to abnormal postures. DYTJ patients manifest progressive generalized dopa-unresponsive dystonia developmental malformations and sensory hearing loss. Ref. 20Miscellaneous: In vertebrates 3 main groups of actin isoforms alpha beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Sequence similaritiesBelongs to the actin family. 1. McKenzie J. L. and Fabre J. W. (1981) Human Thy-1: Unusual localization and possible functional significance in lymphoid tissues. J. Immunol. 126: 843-850. 2. Daar A. S. and Fabre J. W. (1981) Demonstration with monoclonal antibodies of an unusual mononuclear cell infiltrate and loss of normal epithelial membrane antigens in human breast carcinomas. Lancet. 2: 434-438. 3. Yoshino N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49 (2): 97-110. 4. Fiegal H. C. et al. (2004) Stem-like cells in human hepatoblastoma. J. Histochem. Cytochem. 52: 1495-1501. 5. Hagood J. S. et al. (2005) Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am. J. Pathol. 167: 365-379.