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RABBIT ANTI HUMAN PI3-KINASE p110 SUBUNIT DELTA (C-TERMINAL)

RABBIT ANTI HUMAN PI3-KINASE p110 SUBUNIT DELTA (C-TERMINAL)

Item no.	18-783-313611
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Mesothelioma Western Blot Autophagy Cardiovascular Research Proliferation Myocardial Infarction Primary Antibodies
Type	Antibody
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-F26DE0
Similar products	18-783-313611
Available
Genway ID:	GWB-F26DE0
Specificity:	PI3-KINASE p110 SUBUNIT DELTA (C-TERMINAL)
Isotype:	Polyclonal IgG
Buffer Solution:	KHPO4 pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 0. 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:	Synthetic peptide SWKTKVNWLAHNVSKDNRQ with added cysteine corresponding to amino acids 1026-1044 within the C-terminal region of human PI3-Kinase p110 subunit delta.
Specificity:	Specifically recognises an epitope within the C-terminal (CT) region of human PI3-kinase p110 subunit delta (Phosphatidylinositol-4 5-bisphosphate 3-kinase catalytic subunit delta) a member of the PI3/PI4-kinase family of lipid kinases implicated in the regulation of signal transduction during cell growth. PI3-kinase is a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit which itself is divided into isoforms p110alpha p110beta p110delta and p110gamma. Studies have shown that p110delta is predominantly restricted to leucocytes exhibits a broad phosphoinositide lipid substrate specificity and binds to Ras-GTP and p85.
Specificity:	Is reported as suitable for use in immunocytochemistry. Recommended Positive Controls: JURKAT CELL TOTAL PROTEIN LYSATERecommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)
Catalytic Activity:	ATP + 1-phosphatidyl-1D-myo-inositol 4 5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3 4 5-trisphosphate.
Pathway:	Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. Subunit structureHeterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS By similarity. Tissue specificityExpressed predominantly in leukocytes. Post-translational modificationAutophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity. Sequence similaritiesBelongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/11/2025

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