RABBIT ANTI HUMAN CD136

CD136

Phosphate buffered saline pH7. 7

Synthetic peptide: internal domain of human CD136 conjugated to keyhole limpet hemocyanin.

Receptor for macrophage stimulating protein (MSP). Has a tyrosine-protein kinase activity. Ref. 5Catalytic activityATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Subunit structureHeterodimer formed of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityKeratinocytes and lung. Post-translational modificationProteolytic processing yields the two subunits. Phosphorylated in response to ligand binding Probable. Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Contains 3 IPT/TIG domains. Contains 1 protein kinase domain. Contains 1 Sema domain. 1. Coffman R. (1982) Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69: 5-23. 2. Rosmalen J. G. M. et al. (2000) Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. Lab. Invest. 80:23-30. 3. Whiteland J. L. et al. (1995) Immunohistochemical detection of T-Cell subsets and other leucocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J. Histochem. Cytochem. 43: 313-320. 4. Spangrude G. J. et al. (1988) Purification and characterization of mouse hematopoietic stem cells. Science. 241:58-62. 5. Spangrude G. J. et al. (1988) Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus. J. Exp. Med. 167(5):1671-1683. 6. Holmes K. L. et al. (1986) Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts. J. Immunol. 137(2):679-688. 7. Monteith. C. E. et al. (1996) Identification of monoclonal antibodies for immunohistochemical staining of feline B lymphocytes in frozen and formalin fixed paraffin embedded tissues. Can. J. Vet. Res. 60: 193-198. [1] \" Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA. \" Saga Y. Tung J. -S. Shen F. -W. Boyse E. A. Proc. Natl. Acad. Sci. U. S. A. 83:6940-6944(1986) [PubMed: 2944116] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). [2] ErratumSaga Y. Tung J. -S. Shen F. -W. Boyse E. A. Proc. Natl. Acad. Sci. U. S. A. 84:1991-1991(1987)Cited for: SEQUENCE REVISION. [3] \" Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles. \" Zebedee S. L. Barritt D. S. Raschke W. C. Dev. Immunol. 1:243-254(1991) [PubMed: 1822988] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c. [4] \" Alternative use of 5\' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages. \" Saga Y. Tung J. -S. Shen F. -W. W. Boyse E. A. Proc. Natl. Acad. Sci. U. S. A. 84:5364-5368(1987) [PubMed: 3037546] [Abstract]Cited for: NUCLEOTIDE SEQUENCE OF 1-226 (ISOFORM 2). [5] \" Organization of the Ly-5 gene. \" Saga Y. Tung J. -S. Shen F. -W. W. Pancoast T. C. Boyse E. A. Mol. Cell. Biol. 8:4889-4895(1988) [PubMed: 3211131] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22. [6] \" Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene. \" Johnson N. A. Meyer C. M. Pingel J. T. Thomas M. L. J. Biol. Chem. 264:6220-6229(1989) [PubMed: 2522930] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22. [7] \" Cloning of Ly-5 cDNA. \" Shen F. -W. Saga Y. Litman G. Freeman G. Tung J. -S. Cantor H. Boyse E. A. Proc. Natl. Acad. Sci. U. S. A. 82:7360-7363(1985) [PubMed: 3864163] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-263 (ISOFORM 3). Tissue: T-cell. [8] \" Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals. \" Tung J. -S. Saga Y. Boyse E. A. Immunogenetics 28:271-277(1988) [PubMed: 3417340] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-73. [9] \" Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. \" Yi T. Cleveland J. L. Ihle J. N. Blood 78:2222-2228(1991) [PubMed: 1932742] [Abstract]Cited for: NUCLEOTIDE SEQUENCE OF 730-838. [10] \" Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages. \" Raschke W. C. Proc. Natl. Acad. Sci. U. S. A. 84:161-165(1987) [PubMed: 2948186] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 961-1291.