RABBIT ANTI HUMAN FAM129A

FAM129A

Phosphate buffered saline

A synthetic peptide sequence corresponding to amino acid 908 - 920 of human FAM129A.

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response By similarity. Subcellular locationCytoplasmRef. 8. Tissue specificityExpressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart skeletal muscle pancreas white blood cells and prostate with moderate expression in colon and spleen. Expressed in renal carcinoma cells but not in normal kidney. Ref. 8Ref. 1Miscellaneous: \' Niban\' means \' second\' in Japanese. Sequence similaritiesBelongs to the Niban family. Sequence cautionThe sequence BAB17230. 1 differs from that shown. Reason: Erroneous initiation. 1. Petering H. et al. (1999) The Biologic Role of Interleukin-8: Functional Analysis and Expression of CXCR1 and CXCR2 on Human Eosinophils. Blood. 93: 694-702. 2. Zahn S. et al. (1997) Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid. Eur. J. Immunol. 27: 935-40. [1] \" Cloning of complementary DNA encoding a functional human interleukin-8 receptor. \" Murphy P. M. Tiffany H. L. Science 253:1280-1283(1991) [PubMed: 1891716] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Molecular characterization of receptors for human interleukin-8 GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. \" Cerretti D. P. Kozlosky C. J. Vanden Bos T. Nelson N. Gearing D. P. Beckmann M. P. Mol. Immunol. 30:359-367(1993) [PubMed: 8384312] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] CHARACTERIZATION. [3] \" Structure genomic organization and expression of the human interleukin-8 receptor B gene. \" Sprenger H. Lloyd A. R. Lautens L. L. Bonner T. I. Kelvin D. J. J. Biol. Chem. 269:11065-11072(1994) [PubMed: 7512557] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. [4] \" Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. \" Ahuja S. K. Shetty A. Tiffany H. L. Murphy P. M. J. Biol. Chem. 269:26381-26389(1994) [PubMed: 7929358] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. [5] SeattleSNPs variation discovery resourceSubmitted (AUG-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [7] \" Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1 CXCR2 and CXCR3. \" Kato H. Tsuchiya N. Tokunaga K. Genes Immun. 1:330-337(2000) [PubMed: 11196695] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-162 AND 191-301 VARIANT CYS-80. [8] \" Characterization of two high affinity human interleukin-8 receptors. \" Lee J. Horuk R. Rice G. C. Bennett G. L. Camerato T. Wood W. I. J. Biol. Chem. 267:16283-16287(1992) [PubMed: 1379593] [Abstract]Cited for: CHARACTERIZATION. [9] \" Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. \" Mueller S. G. White J. R. Schraw W. P. Lam V. Richmond A. J. Biol. Chem. 272:8207-8214(1997) [PubMed: 9079638] [Abstract]Cited for: PHOSPHORYLATION AT SER-347; SER-351; SER-352 AND SER-353.