RABBIT ANTI HUMAN ACINUS

ACINUS

Phosphate buffered Saline

Peptide DTSENRPENDVPEPP which corresponds to a region within Acinus.

Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Ref. 1Subunit structureFound in a mRNA splicing-dependent exon junction complex (EJC) at least composed of ACIN1 CASC3 EIF4A3 MAGOH PNN RBM8A RNPS1 SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1 RNPS1 and SAP18. Interacts with API5. Ref. 5Ref. 21Subcellular locationNucleusRef. 5. Tissue specificityUbiquitous. Post-translational modificationUndergoes proteolytic cleavage; the processed form is active contrary to the uncleaved form. Sequence similaritiesContains 1 SAP domain. 1. Abrams J. S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples Immunol. Rev. 127: 5-24. 2. Bauman. S. et al. (2003) Effects of tumor necrosis factor alpha on dendritic cell accumulation in lymph nodes draining the immunization site and the impact on the anticryptococcal cell-mediated immune response. Infect. Immun. 71:68 - 74. 3. Tsao. N. et al. (1999) Inhibition of Escherichia coli-induced meningitis by carboxyfullerence. Antimicrobial Agents. Chemother. 43:2273-2277. 4. Bennouna S. et al. (2003) Cross-talk in the innate immune system: Neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J. Immunol. 171:6052-6058. [1] \" Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor. \" Shirai T. Shimizu N. Shiojiri S. Horiguchi S. Ito H. DNA 7:193-201(1988) [PubMed: 2836146] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [2] \" Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. \" Pennica D. Hayflick J. S. Bringman T. S. Palladino M. A. Goeddel D. V. Proc. Natl. Acad. Sci. U. S. A. 82:6060-6064(1985) [PubMed: 3898078] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Identification of a common nucleotide sequence in the 3\' -untranslated region of mRNA molecules specifying inflammatory mediators. \" Caput D. Beutler B. Hartog K. Thayer R. Brown-Shimer S. Cerami A. Proc. Natl. Acad. Sci. U. S. A. 83:1670-1674(1986) [PubMed: 2419912] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. \" Fransen L. Mueller R. Marmenout A. Tavernier J. van der Heyden J. Kawashima E. Chollet A. Tizard R. van Heuverswyn H. van Vliet A. Ruysschaert M. -R. Fiers W. Nucleic Acids Res. 13:4417-4429(1985) [PubMed: 2989794] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice. \" Shakhov A. N. Nedospasov S. A. Bioorg. Khim. 13:701-705(1987) [PubMed: 3040015] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. [6] \" Nucleotide sequence of the murine TNF locus including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes. \" Semon D. Kawashima E. Jongeneel C. V. Shakhov A. N. Nedospasov S. A. Nucleic Acids Res. 15:9083-9084(1987) [PubMed: 3684584] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [7] \" Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. \" Ikegami H. Makino S. Yamato E. Kawaguchi Y. Ueda H. Sakamoto T. Takekawa K. Ogihara T. J. Clin. Invest. 96:1936-1942(1995) [PubMed: 7560085] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CTS and NOD. [8] \" Cloning and sequencing of the Tnfa genes of three inbred mouse strains. \" Iraqi F. Teale A. Immunogenetics 45:459-461(1997) [PubMed: 9089109] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS THR-7 AND ALA-77. Strain: A/J BALB/c and C57BL/6. [9] \" Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. \" Xie T. Rowen L. Aguado B. Ahearn M. E. Madan A. Qin S. Campbell R. D. Hood L. Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129. [10] \" Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies. \" Liu Y. Kitano T. Koide T. Shiroishi T. Moriwaki K. Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE OF 1-96. Strain: BFM/2Msf BLG2/Msf C57BL/10SnJ CAST/Ei HMI/Msf MSM/Msf NJL/Msf pgn2 and SWN/Msf.