RABBIT ANTI HUMAN CD156c

GWB-887DD9

Polyclonal IgG

Synthetic peptide corresponding to the amino terminal end of active CD156c.

Cleaves the membrane-bound precursor of TNF-alpha at \' 76-Ala-|-Val-77\' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins including heparin-binding epidermal growth-like factor ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis By similarity. Ref. 4Ref. 5Ref. 7Catalytic activityEndopeptidase of broad specificity. Cofactor: Binds 1 zinc ion By similarity. Subunit structureInteracts with ephrin-A2 By similarity. Subcellular locationCell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein.

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Post-translational modificationThe precursor is cleaved by a furin endopeptidase By similarity. Sequence similaritiesContains 1 disintegrin domain. Contains 1 peptidase M12B domain. 1. Lottaz C. et al. (2010) Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin Cancer Res. 70: 2030-40. 2. Modjtahedi H. et al. (1993) Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor. Cell Biophys. 1993. 22 (1-3): 129-146. [1] \" Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. \" Ullrich A. Coussens L. Hayflick J. S. Dull T. J. Gray A. Tam A. W. Lee J. Yarden Y. Libermann T. A. Schlessinger J. Downward J. Mayes E. L. V. Whittle N. Waterfield M. D. Seeburg P. H. Nature 309:418-425(1984) [PubMed: 6328312] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [2] \" Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta. \" Ilekis J. V. Stark B. C. Scoccia B. Mol. Reprod. Dev. 41:149-156(1995) [PubMed: 7654368] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta. [3] \" A 1. 8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor. \" Reiter J. L. Maihle N. J. Nucleic Acids Res. 24:4050-4056(1996) [PubMed: 8918811] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2). Tissue: Placenta. [4] \" Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer. \" Ilekis J. V. Gariti J. Niederberger C. Scoccia B. Gynecol. Oncol. 65:36-41(1997) [PubMed: 9103388] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). Tissue: Placenta. [5] \" Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. \" Reiter J. L. Threadgill D. W. Eley G. D. Strunk K. E. Danielsen A. J. Schehl Sinclair C. Pearsall R. S. Green P. J. Yee D. Lampland A. L. Balasubramaniam S. Crossley T. D. Magnuson T. R. James C. D. Maihle N. J. Genomics 71:1-20(2001) [PubMed: 11161793] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4). Tissue: Placenta. [6] \" Cloning of the cDNA for a short EGF receptor from human placenta. \" Xu L. Hong A. He X. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [7] NIEHS SNPs programSubmitted (APR-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS GLN-98; ARG-266; LYS-521; ILE-674; GLY-962 AND PRO-988. [8] \" Human and mouse alternative EGFR transcripts encoding only the extracellular domain of the receptor. \" Reiter J. L. Threadgill D. W. Danielsen A. J. Schehl C. M. Lampland A. L. Balasubramaniam S. Crossley T. O. Magnuson T. R. Maihle N. J. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 575-687. [9] \" Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. \" Lin C. R. Chen W. S. Kruiger W. Stolarsky L. S. Weber W. Evans R. M. Verma I. M. Gill G. N. Rosenfeld M. G. Science 224:843-848(1984) [PubMed: 6326261] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 713-924. [10] \" Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. \" Xu Y. H. Ishii S. Clark A. J. L. Sullivan M. Wilson R. K. Ma D. P. Roe B. A. Merlino G. T. Pastan I. Nature 309:806-810(1984) [PubMed: 6330563] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-962.