Human Serum Albumin [1.B.731]

1. B. 731

Full length native protein (purified) (Human).

No crossreactivity with other human proteins tested. Does not crossreact with BSA or egg white albumin.

Secreted

0. 1% Sodium Azide. Constituents: 40% Glycerol PBS. pH 7. 4

Secreted Myeloma: Sp2/0 Albumin is a soluble monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids fatty acids and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in this gene on chromosome 4 result in various anomalous proteins. Albumin is a globular unglycosylated serum protein of molecular weight 65 000. The human albumin gene is 16 961 nucleotides long from the putative \' cap\' site to the first poly(A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product proalbumin is in turn cleaved in the Golgi vesicles to produce the secreted albumin.

Secreted.

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.

The sequence shown is that of variant albumin A.

A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood [MIM:194470].

Belongs to the ALB/AFP/VDB family.