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MOUSE ANTI HUMAN SPECTRIN ALPHA/BETA

MOUSE ANTI HUMAN SPECTRIN ALPHA/BETA

Manufacturer	GENWAY
Category	Antibodies Primary Antibodies
Type	Antibody
Specific against	Human
Amount	1 mg
Host	Mouse
Item no.	20-783-314253
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-A81C00
Specificity:	SPECTRIN ALPHA/BETA
Isotype:	IgM
Preparation:	Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgM concentration 1. 0 mg/ml
Immunogen:	Native human beta spectrin
Specificity:	Specific for the alpha (240 kD) and beta (220 kD) subunits of human spectrin. This antibody has not been cross-adsorbed and may react with peptides from related species. Recommended Secondary Antibodies: Goat Anti Mouse IgMGoat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgM
Function:	Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4. 1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Subunit structureComposed of nonhomologous chains alpha and beta which aggregate to form dimers tetramers and higher polymers. Subcellular locationCytoplasm & rsaquo; cytoskeleton. Cytoplasm & rsaquo; cell cortex. Post-translational modificationThe first phosphorylation event occurs on Ser-2114 followed by Ser-2125 Ser-2123 Ser-2128 Ser-2117 and Thr-2110. Involvement in diseaseDefects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis a genetically heterogeneous autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Ref. 15Ref. 17Ref. 18Ref. 19Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
Miscellaneous:	This complex is anchored to the cytoplasmic face of the plasma membrane via another protein ankyrin which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane. Sequence similaritiesBelongs to the spectrin family. Contains 2 CH (calponin-homology) domains. Contains 17 spectrin repeats. [1] \" H2A. X. a histone isoprotein with a conserved C-terminal sequence is encoded by a novel mRNA with both DNA replication type and polyA 3\' processing signals. \"

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Amount: 1 mg

available

Delivery expected until 5/30/2024