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MOUSE ANTI HUMAN CD253:Low Endotoxin

MOUSE ANTI HUMAN CD253:Low Endotoxin

Item no.	20-783-314303
Manufacturer	GENWAY
Amount	0.5 mg
Category	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Type	Antibody
Applications	WB
Specific against	Human (Homo sapiens)
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AC7212
Similar products	20-783-314303
Available
Genway ID:	GWB-AC7212
Specificity:	CD253
Isotype:	IgG1
Preparation:	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		None presentApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
Immunogen:	Recombinant human CD253 (TRAIL) aa 95-281.
Specificity:	Recognises the 281 amino acid protein termed TNF related apoptosis-inducing ligand (TRAIL) also known as CD253. TRAIL is a cytotoxic protein closely related to Fas (CD95) which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors DcR1 and DcR2 which antagonise TRAIL activity. TRAIL is expressed by cell lines activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy. This antibody neutralises TRAIL activity. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:Low EndotoxinRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:	Cytokine that binds to TNFRSF10A/TRAILR1 TNFRSF10B/TRAILR2 TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3 TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Cofactor: Binds 1 zinc ion per trimer. Subunit structureHomotrimer. Subcellular locationMembrane; Single-pass type II membrane protein Potential. Tissue specificityWidespread; most predominant in spleen lung and prostate. Sequence similaritiesBelongs to the tumor necrosis factor family. 1. Seinost G. et al (1999) Four Clones of Borrelia burgdorferi Sensu Stricto Cause Invasive Infection in Humans. Infect. Immun. 67: 3518-35242. Aguero-Rosenfeld M. E. et al (2005) Diagnosis of Lyme Borreliosis. Clin. Microbiol. Rev. 18: 484-509

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

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Delivery expected until 11/27/2025

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