MOUSE ANTI HUMAN MUCIN 2:FITC

MUCIN 2

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises human Mucin 2 (MUC-2) and shows no cross-reactivity with MUC-1 MUC-3 or MUC-4. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC

In the intestine secreted into the inner and outer mucus layers By similarity. Tissue specificityColon small intestine colonic tumors bronchus cervix and gall bladder. Post-translational modificationO-glycosylated. Ref. 6May undergo proteolytic cleavage in the outer mucus layer of the colon contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria By similarity. At low pH of 6 and under undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.