MOUSE ANTI HUMAN CD85a

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314619
Available
Genway ID:
GWB-10668D
Specificity:
CD85a
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Monocyte derived dendritic cells
Specificity:
Is specific for human CD85a (leucocyte immunoglobulin-like receptor subfamily B member 3/ LILRB3) also known as ILT-5 expressed by monocytes dendritic cells macrophages subpopulation of T lymphocytes B cells and at high levels on plasma cells. CD85a is a 631 amino acid type I transmembrane glycoprotein which contains four immunoreceptor tyrosine-based inhibition motif (ITIM) sequences within a long cytoplasmic tail. Phosphorylation of the tyrosine residues within ITIMs is known to enable the binding and activation of protein tyrosine phosphatases which act as cell signalling modulators and inhibitors of cell activation. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
May act as receptor for class I MHC antigens. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityDetected in monocytes and B-cells. Ref. 2
Domain:
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Miscellaneous:
Belongs to the leukocyte receptor cluster (LRC) present on 19q13. 4. Sequence similaritiesContains 4 Ig-like C2-type (immunoglobulin-like) domains. [1] \" Molecular and biological characterization of human 4-1BB and its ligand. \" Alderson M. R. Smith C. A. Tough T. W. Davis-Smith T. Armitage R. J. Falk B. Roux E. Baker E. Sutherland G. R. Din W. S. Goodwin R. G. Eur. J. Immunol. 24:2219-2227(1994) [PubMed: 8088337] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. [3] \" The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. \" Won E. Y. Cha K. Byun J. S. Kim D. U. Shin S. Ahn B. Kim Y. H. Rice A. J. Walz T. Kwon B. S. Cho H. S. J. Biol. Chem. 285:9202-9210(2010) [PubMed: 20032458] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 3 ANGSTROMS) OF 80-246 FUNCTION SUBUNIT.
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Discount: -10.0%
Price: €293.57
You save: €32.62
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