MOUSE ANTI HUMAN CD61

CD61

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises CD61 a 105kD glycoprotein which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41 and on endothelial cells monocytes platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen fibronectin vWF vitronectin and thrombospondin. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)

Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59. HPA-1A is involved in fetal-maternal alloimmune thromobocytopenia (FMAIT) as well as in neonatal alloimmune thrombocytopenia (NAIT). Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). Position 433 is associated with platelet-specific alloantigen MO. MO- has Pro-433 and MO+ has Ala-433. MO+ is involved in NAIT. Position 515 is associated with platelet-specific alloantigen CA/TU. CA-/TU- has Arg-515 and CA+/TU+ has Gln-515. CA+ is involved in NAIT. Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)- has Arg-662 and SR(A)+ has Cys-662. Involvement in diseaseDefects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls) have detectable amounts of fibrinogen and have low or moderate clot retraction capability. The platelets of GT \' variants\' have normal or near normal (60-100%) expression of dysfunctional receptors. Ref. 38Ref. 39Ref. 40Ref. 41Ref. 42Ref. 43Ref. 44Ref. 45Ref. 46Ref. 47Ref. 50Ref. 52Ref. 53Ref. 54Ref. 55Ref. 56Ref. 57Sequence similaritiesBelongs to the integrin beta chain family. Contains 1 VWFA domain. [1] \" Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. \" Power C. A. Meyer A. Nemeth K. Bacon K. B. Hoogewerf A. J. Proudfoot A. E. I. Wells T. N. C. J. Biol. Chem. 270:19495-19500(1995) [PubMed: 7642634] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen. [2] \" New variations of human CC-chemokine receptors CCR3 and CCR4. \" Kato H. Tsuchiya N. Izumi S. Miyamasu M. Nakajima T. Kawasaki H. Hirai K. Tokunaga K. Genes Immun. 1:97-104(1999) [PubMed: 11196669] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS VAL-130 AND SER-178. [3] \" cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). \" Kopatz S. A. Aronstam R. S. Sharma S. V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood. [5] \" The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. \" Imai T. Baba M. Nishimura M. Kakizaki M. Takagi S. Yoshie O. J. Biol. Chem. 272:15036-15042(1997) [PubMed: 9169480] [Abstract]Cited for: FUNCTION. [6] \" Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. \" Imai T. Chantry D. Raport C. J. Wood C. L. Nishimura M. Godiska R. Yoshie O. Gray P. W. J. Biol. Chem. 273:1764-1768(1998) [PubMed: 9430724] [Abstract]Cited for: FUNCTION. [7] \" The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. \" Campbell J. J. Haraldsen G. Pan J. Rottman J. Qin S. Ponath P. Andrew D. P. Warnke R. Ruffing N. Kassam N. Wu L. Butcher E. C. Nature 400:776-780(1999) [PubMed: 10466728] [Abstract]Cited for: FUNCTION. [8] \" Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine macrophage-derived chemokine and I-309. \" Inngjerdingen M. Damaj B. Maghazachi A. A. J. Immunol. 164:4048-4054(2000) [PubMed: 10754297] [Abstract]Cited for: FUNCTION TISSUE SPECIFICITY PHOSPHORYLATION.