MOUSE ANTI HUMAN CD275:FITC

GWB-24D763

IgG1

Phosphate buffered saline pH7. 4

CD275 - L cells

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions as well as in modulating the secondary immune response by co-stimulating memory T-cell function By similarity. Subcellular locationMembrane; Single-pass type I membrane protein By similarity. Tissue specificityIsoform 1 is widely expressed (brain heart kidney liver lung pancreas placenta skeletal muscle bone marrow colon ovary prostate testis lymph nodes leukocytes spleen thymus and tonsil) while isoform 2 is detected only in lymph nodes leukocytes and spleen. Expressed on activated monocytes and dendritic cells. Ref. 7Induction: Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes while it is decreased in dendritic cells. Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Sequence cautionThe sequence BAA31628. 1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA31628. 1 differs from that shown. Reason: The sequence differs from that shown in position 300 onward for unknown reason. 1. Harris K. W. et al. (1992) Ligand binding properties of the human erythropoietin receptor extracellular domain expressed in Escherichia coli. J. Biol. Chem. 267: 15205-15209. [1] \" The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. \" Winkelmann J. C. Penny L. A. Deaven L. L. Forget B. G. Jenkins R. B. Blood 76:24-30(1990) [PubMed: 2163695] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [2] \" Human erythropoietin receptor: cloning expression and biologic characterization. \" Jones S. S. D\' Andrea A. D. Haines L. L. Wong G. G. Blood 76:31-35(1990) [PubMed: 2163696] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F). Tissue: Erythroleukemia and Fetal liver. [3] \" Cloning of the human erythropoietin receptor gene. \" Noguchi C. T. Bae K. S. Chin K. Wada Y. Schechter A. N. Hankins W. D. Blood 78:2548-2556(1991) [PubMed: 1668606] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. [4] \" The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1. \" Ehrenman K. St John T. Exp. Hematol. 19:973-977(1991) [PubMed: 1654273] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F). Tissue: Erythroleukemia. [5] \" A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. \" Nakamura Y. Komatsu N. Nakauchi H. Science 257:1138-1141(1992) [PubMed: 1324524] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EPOR-F; EPOR-S AND EPOR-T). Tissue: Bone marrow and Megakaryoblast. [6] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EPOR-F). Tissue: Caudate nucleus. [7] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [8] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EPOR-F). Tissue: Brain. [9] \" Cloning of the gene encoding the human erythropoietin receptor. \" Maouche L. Tournamille C. Hattab C. Boffa G. Cartron J. -P. Chretien S. Blood 78:2557-2563(1991) [PubMed: 1668607] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96. Tissue: Placenta. [10] \" Genomic organization of the human erythropoietin receptor gene. \" Penny L. A. Forget B. G. Genomics 11:974-980(1991) [PubMed: 1664413] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.