Comparison

MOUSE ANTI HUMAN DECTIN-1:FITC

Item no. 20-783-315139
Manufacturer GENWAY
Amount 25 ug
Category
Type Antibody
Specific against Human (Homo sapiens)
Host Mouse
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-28ACF3
Similar products 20-783-315139
Available
Genway ID:
GWB-28ACF3
Specificity:
DECTIN-1
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:
NIH3T3 cells expressing full length Beta-glucan receptor.
Specificity:
Recognises human Dectin-1 also known as beta-glucan receptor (& #223; GR) a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans glucose polymers that form cell-wall components or exopolymers of yeasts fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial yeast viral and protozoan infections as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (& #223; GR-A and & #223; GR-B) and several minor isoforms. & #223; GR-A and & #223; GR-B differs by the presence and absence respectively of a stalk region.
Specificity:
(clone GE2) Recognises both of these isoforms. Clone GE2 could be used to inhibit receptor function. Recommended for functional assays. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC 1. Scita G. et al. (2000) Signaling from Ras to Rac and beyond: not just a matter of GEFs. EMBO J. 19: 2393-2398. [1] \" Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. \" Chardin P. Camonis J. H. Gale N. W. van Aelst L. Wigler M. H. Bar-Sagi D. Science 260:1338-1343(1993) [PubMed: 8493579] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. [2] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 ug
Available: In stock
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