MOUSE ANTI HUMAN CD4:RPE

GWB-C30401

IgG1

Phosphate buffered saline pH7. 4

Human PHA blasts

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Subunit structureAssociates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Ref. 15Ref. 18Ref. 19Ref. 21Subcellular locationCell membrane; Single-pass type I membrane protein.

Primary receptor for HIV-1. Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Pommier Y. et al. (2006) Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors. Clin. Cancer Res. 12: 2657-2661. [1] \" A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. \" Helin K. Lees J. A. Vidal M. Dyson N. J. Harlow E. Fattaey A. Cell 70:337-350(1992) [PubMed: 1638634] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. \" Kaelin W. G. Jr. Krek W. Sellers W. R. Decaprio J. A. Ajchenbaum F. Fuchs C. S. Chittenden T. Li Y. Farnham P. J. Blanar M. A. Livingston D. M. Flemington E. K. Cell 70:351-364(1992) [PubMed: 1638635] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. \" Shan B. Zhu X. Chen P. L. Durfee T. Yang Y. Sharp D. Lee W. H. Mol. Cell. Biol. 12:5620-5631(1992) [PubMed: 1448092] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Structure and partial genomic sequence of the human E2F1 gene. \" Neuman E. Sellers W. R. S. McNeil J. A. Lawrence J. B. Kaelin W. G. Jr. Gene 173:163-169(1996) [PubMed: 8964493] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [5] NIEHS SNPs programSubmitted (MAY-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS HIS-252; MET-276; ASN-311 AND SER-393. [6] \" The DNA sequence and comparative analysis of human chromosome 20. \" Deloukas P. Matthews L. H. Ashurst J. L. Burton J. Gilbert J. G. R. Jones M. Stavrides G. Almeida J. P. Babbage A. K. Bagguley C. L. Bailey J. Barlow K. F. Bates K. N. Beard L. M. Beare D. M. Beasley O. P. Bird C. P. Blakey S. E. Bridgeman A. M. Brown A. J. Buck D. Burrill W. D. Butler A. P. Carder C. Carter N. P. Chapman J. C. Clamp M. Clark G. Clark L. N. Clark S. Y. Clee C. M. Clegg S. Cobley V. E. Collier R. E. Connor R. E. Corby N. R. Coulson A. Coville G. J. Deadman R. Dhami P. D. Dunn M. Ellington A. G. Frankland J. A. Fraser A. French L. Garner P. Grafham D. V. Griffiths C. Griffiths M. N. D. Gwilliam R. Hall R. E. Hammond S. Harley J. L. Heath P. D. Ho S. Holden J. L. Howden P. J. Huckle E. Hunt A. R. Hunt S. E. Jekosch K. Johnson C. M. Johnson D. Kay M. P. Kimberley A. M. King A. Knights A. Laird G. K. Lawlor S. Lehvaeslaiho M. H. Leversha M. A. Lloyd C. Lloyd D. M. Lovell J. D. Marsh V. L. Martin S. L. McConnachie L. J. McLay K. McMurray A. A. Milne S. A. Mistry D. Moore M. J. F. Mullikin J. C. Nickerson T. Oliver K. Parker A. Patel R. Pearce T. A. V. Peck A. I. Phillimore B. J. C. T. Prathalingam S. R. Plumb R. W. Ramsay H. Rice C. M. Ross M. T. Scott C. E. Sehra H. K. Shownkeen R. Sims S. Skuce C. D. Smith M. L. Soderlund C. Steward C. A. Sulston J. E. Swann R. M. Sycamore N. Taylor R. Tee L. Thomas D. W. Thorpe A. Tracey A. Tromans A. C. Vaudin M. Wall M. Wallis J. M. Whitehead S. L. Whittaker P. Willey D. L. Williams L. Williams S. A. Wilming L. Wray P. W. Hubbard T. Durbin R. M. Bentley D. R. Beck S. Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Skin. [8] \" Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. \" Johnson D. G. Ohtani K. Nevins J. R. Genes Dev. 8:1514-1525(1994) [PubMed: 7958836] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-111. [9] \" Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. \" Helin K. Harlow E. Fattaey A. Mol. Cell. Biol. 13:6501-6508(1993) [PubMed: 8413249] [Abstract]Cited for: TRANSACTIVATION INHIBITION MUTAGENESIS OF TYR-411. [10] \" Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. \" Krek W. Ewen M. E. Shirodkar S. Arany Z. Kaelin W. G. Jr. Livingston D. M. Cell 78:161-172(1994) [PubMed: 8033208] [Abstract]Cited for: DOMAIN CYCLIN A/CDK2 BINDING.