MOUSE ANTI HUMAN CD13:APC

GWB-6B2062

IgG1Species Cross Reactivity: Reacts with: Rhesus MonkeyN. B. Antibody reactivity and working conditions may vary between species.

Phosphate buffered saline pH7. 4

Human AML cells

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells macrophages granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Ref. 11Ref. 13Ref. 14Ref. 15Ref. 17Ref. 18Ref. 19Ref. 20Ref. 22Catalytic activityRelease of an N-terminal amino acid Xaa-|-Yaa- from a peptide amide or arylamide. Xaa is preferably Ala but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue the two may be released as an intact Xaa-Pro dipeptide. Cofactor: Binds 1 zinc ion per subunit By similarity. Subunit structureHomodimer. Interacts with the S1 domain of HCoV-229E spike protein. Ref. 11Ref. 9Ref. 23Subcellular locationCell membrane; Single-pass type II membrane protein. Cytoplasm & rsaquo; cytosol Potential.

Estradiol and IL-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30% respectively. Ref. 20

Found to serve as a receptor for tumor-homing peptides more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile varies from 17. 3 to 57. 6 micrograms/ml. Sequence similaritiesBelongs to the peptidase M1 family. 1. Kang X. et al. (2006) Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas. Cancer Gene Ther. 13: 385-392. [1] \" A novel brain-specific p53-target gene BAI1 containing thrombospondin type 1 repeats inhibits experimental angiogenesis. \" Nishimori H. Shiratsuchi T. Urano T. Kimura Y. Kiyono K. Tatsumi K. Yoshida S. Ono M. Kuwano M. Nakamura Y. Tokino T. Oncogene 15:2145-2150(1997) [PubMed: 9393972] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. [2] \" Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. \" Shiratsuchi T. Futamura M. Oda K. Nishimori H. Nakamura Y. Tokino T. Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed: 9647739] [Abstract]Cited for: INTERACTION WITH MAGI1. [3] \" Identification of BAIAP2 (BAI-associated protein 2) a novel human homologue of hamster IRSp53 whose SH3 domain interacts with the cytoplasmic domain of BAI1. \" Oda K. Shiratsuchi T. Nishimori H. Inazawa J. Yoshikawa H. Taketani Y. Nakamura Y. Tokino T. Cytogenet. Cell Genet. 84:75-82(1999) [PubMed: 10343108] [Abstract]Cited for: INTERACTION WITH BAIAP2. [4] \" Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3 a novel membrane-associated guanylate kinase. \" Wu Y. Dowbenko D. Spencer S. Laura R. Lee J. Gu Q. Lasky L. A. J. Biol. Chem. 275:21477-21485(2000) [PubMed: 10748157] [Abstract]Cited for: INTERACTION WITH MAGI3. [5] \" Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. \" Duda D. G. Sunamura M. Lozonschi L. Yokoyama T. Yatsuoka T. Motoi F. Horii A. Tani K. Asano S. Nakamura Y. Matsuno S. Br. J. Cancer 86:490-496(2002) [PubMed: 11875720] [Abstract]Cited for: FUNCTION TISSUE SPECIFICITY. [6] \" Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. \" Mori K. Kanemura Y. Fujikawa H. Nakano A. Ikemoto H. Ozaki I. Matsumoto T. Tamura K. Yokota M. Arita N. Neurosci. Res. 43:69-74(2002) [PubMed: 12074842] [Abstract]Cited for: TISSUE SPECIFICITY SUBCELLULAR LOCATION. [7] \" Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. \" Kaur B. Brat D. J. Calkins C. C. Van Meir E. G. Am. J. Pathol. 162:19-27(2003) [PubMed: 12507886] [Abstract]Cited for: TISSUE SPECIFICITY.