MOUSE ANTI HUMAN CD282:RPE

CD282

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises human toll-like receptor 2 (TLR2) a 90kD type 1 transmembrane protein that is primarily expressed by peripheral blood monocytes. TLR2 also known as CD282 is reported to respond to a diverse range of bacterial cell wall components mediating the innate immune response in co-operation with MD-2. Recommended Negative Controls: MOUSE IgG2a NEGATIVE CONTROL:RPE

Genetic variations in TLR2 are associated with suceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1 but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy. Sequence similaritiesBelongs to the Toll-like receptor family. Contains 14 LRR (leucine-rich) repeats. Contains 1 TIR domain. [1] \" Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. \" Lagace M. Xuan J. -Y. Young S. S. McRoberts C. Maier J. Rajcan-Separovic E. Korneluk R. G. Genomics 77:181-188(2001) [PubMed: 11597143] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. [2] \" Molecular cloning of ILP-2 a novel member of the inhibitor of apoptosis protein family. \" Richter B. W. M. Mir S. S. Eiben L. J. Lewis J. Reffey S. B. Frattini A. Tian L. Frank S. Youle R. J. Nelson D. L. Notarangelo L. D. Vezzoni P. Fearnhead H. O. Duckett C. S. Mol. Cell. Biol. 21:4292-4301(2001) [PubMed: 11390657] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT HIS-196. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [4] \" The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. \" Shin H. Renatus M. Eckelman B. P. Nunes V. A. Sampaio C. A. Salvesen G. S. Biochem. J. 385:1-10(2005) [PubMed: 15485395] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 2 ANGSTROMS) OF 1-95.