MOUSE ANTI HUMAN CD62P:RPE

GWB-8AB63A

IgG1Species Cross Reactivity: Reacts with: Mouse Horse Bovine Rat Goat Cat SheepN. B. Antibody reactivity and working conditions may vary between species.

Phosphate buffered saline pH7. 4

P-selectin transfected 300. 19 cells.

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Ref. 7Subunit structureInteracts with SNX17. Interacts with PSGL1/SEPL and mediateS neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope and specific tyrosine sulfation on PSGL1. Ref. 7Ref. 6Ref. 8Ref. 9Ref. 10Ref. 14Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists P-selectin is transported rapidly to the cell surface. Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor sensory and/or cognitive function. Ischemic strokes resulting from vascular occlusion is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Ref. 19Sequence similaritiesBelongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 9 Sushi (CCP/SCR) domains. 1. Forsburg S. L. (2004) Eukaryotic MCM proteins: Beyond replication initiation. Microbiol. Mol. Biol. Rev. 68: 109-131. 2. Tsuji T. et al. (2006) Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol. Biol. Cell 17: 4459-4472. [1] \" A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division. \" Todorov I. T. Pepperkok R. Philipova R. N. Kearsey S. E. Ansorge W. Werner D. J. Cell Sci. 107:253-265(1994) [PubMed: 8175912] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION SUBCELLULAR LOCATION VARIANT GLN-166. Tissue: Colon carcinoma. [2] \" Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. \" Nomura N. Miyajima N. Sazuka T. Tanaka A. Kawarabayasi Y. Sato S. Nagase T. Seki N. Ishikawa K. Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow. [3] NIEHS SNPs programSubmitted (JUL-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS GLU-68; PHE-135; THR-396; MET-667 AND THR-727. [4] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANTS ARG-501 AND THR-727. Tissue: Brain Lung Lymph Muscle Placenta and Uterus. [5] \" Homo sapiens DNA replication licensing factor (huMCM2). \" Mimura S. Nishimoto S. Kubota Y. Takisawa H. Nojima H. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-904. Tissue: Cervix carcinoma. [6] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-904. [7] \" The human gene for nuclear protein BM28 (CDCL1) a new member of the early S-phase family of proteins maps to chromosome band 3q21. \" Mincheva A. Todorov I. T. Werner D. Fink T. M. Lichter P. Cytogenet. Cell Genet. 65:276-277(1994) [PubMed: 8258304] [Abstract]Cited for: CHROMOSOMAL LOCATION. [8] \" The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. \" Izumi M. Yanagi K. Mizuno T. Yokoi M. Kawasaki Y. Moon K. Y. Hurwitz J. Yatagai F. Hanaoka F. Nucleic Acids Res. 28:4769-4777(2000) [PubMed: 11095689] [Abstract]Cited for: INTERACTION WITH MCM10. [9] \" Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. \" Cortez D. Glick G. Elledge S. J. Proc. Natl. Acad. Sci. U. S. A. 101:10078-10083(2004) [PubMed: 15210935] [Abstract]Cited for: PHOSPHORYLATION AT SER-108 MUTAGENESIS OF SER-108. [10] \" Large-scale characterization of HeLa cell nuclear phosphoproteins. \" Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. Gygi S. P. Proc. Natl. Acad. Sci. U. S. A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-41 AND THR-106 MASS SPECTROMETRY. Tissue: Cervix carcinoma.