Comparison

Mouse F(ab\&#039,)2 Anti-Human CD19

Item no. 20-787-276046
Manufacturer GENWAY
Amount 100 TESTS
Category
Type Antibody
Applications FC, IHC
Clone SJ25-C1
Specific against Human (Homo sapiens)
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-A9D13B
Similar products 20-787-276046
Available
Genway ID:
GWB-A9D13B
Isotype:
Mouse IgG1
Clone:
SJ25-C1
Characterization:
To insure lot to lot consistency each batch of product is tested by flow cytometry to conform to the characteristics of a standard reference reagent.
Specificity:
CD19CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21 CD81 Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR). ^1-5
Working Dilution:
Flow Cytometry: 10 uL/10^6 cells
Warning:
Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Function:
Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Subunit:
Forms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Phosphorylated upon DNA damage probably by ATM or ATR.
Disease:
Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. McMichael A. K. P. C. L. Beverly S. Cobbold M. J. Crumpton W. Gilks F. M. Gotch N. Hogg M. Horton N. Ling I. C. M. MacLennan D. Y. Mason C. Milstein D. Spiegelhalter and H. Waldmann eds. 1987. Leukocyte Typing III: White Cell Differentiation Antigens Oxford University Press Oxford. Barclay A. N. M. H. Brown S. K. A. Law A. J. McKnight M. G. Tomlinson and P. A. van der Merwe eds. 1997. The Leukocyte Antigens Facts Book 2nd Edition CD19 Section Academic Press New York p. 179. Tedder T. F. L. J. Zhou and P. Engel. 1994. Immunol. Today 14:437. Fearon D. T. and R. H. Carter. 1995. Annu. Rev. Immunol. 13:127. Doody G. M. P. W. Dempsey and D. T. Fearson. 1996. Curr. Opin. Immunol. 8:378.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 TESTS
Available: In stock
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