Mouse Anti-Human CD3

GWB-9F0629

UCHT1

epsilon chain of the CD3/T cell antigen receptor complexCD3 a member of the immunoglobulin superfamily of cell surface receptors is comprised of five invariable chains ranging from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). CD3 is expressed on 70-80% of normal peripheral blood lymphocytes and on 10-20% of thymocytes. It plays a major role in signaling during antigen recognition leading to T cell activation. The monoclonal antibody UCHT1 reacts with the 20 kDa epsilon chain of the CD3/TCR complex. ^1-5

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. McMichael A. K. P. C. L. Beverly S. Cobbold M. J. Crumpton W. Gilks F. M. Gotch N. Hogg M. Horton N. Ling I. C. M. MacLennan D. Y. Mason C. Milstein D. Spiegelhalter and H. Waldmann eds. 1987. Leukocyte Typing III: White Cell Differentiation Antigens Oxford University Press Oxford. Knapp W. B. Dorken W. R. GIlks E. P. Rieber R. E. Schmidt H. Stein A. E. G. K. Von dem Borne eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens Oxford University Press Oxford. Schlossman S. L. Bloumsell W. Gilks J. M. Harlan C. Kishimoto J. Ritz S. Shaw R. Silverstein T. Springer T. F. Tedder and R. F. Todd eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens Oxford University Press Oxford. Barclay A. N. M. H. Brown S. K. A. Law A. J. McKnight M. G. Tomlinson and P. A. van der Merwe eds. 1997. The Leukocyte AntigensFacts Book 2nd Edition CD3 Section Academic Press New York p. 137. Beverly P. C. L. and P. E. Callard. 1981. Eur. J. Immunol. 11:329.