Rat Anti-Human IL-6

Rat IgG1 kappa

COS-7-expressed recombinant human IL-6

Human Interleukin-6 (IL-6)^1-3 (This is a neutralizing antibody) Summary: IL6 is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL6 IL6RA (IL6R; MIM 147880) and the shared signaling receptor gp130 (IL6ST; MIM 600694) (Boulanger et al. 2003 [PubMed 12829785]). [supplied by OMIM]. Abrams J. S. M. -G. Roncarolo H. . Yssel U. Andersson G. J. Gleich and J. E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24. Abrams J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn A. Kruisbeek D. Margulies E. Shevach W. Strober eds. ). John Wiley and Sons New York. Unit 6. 20. Gaines Das R. and S. Poole. 1993. The international standard for IL-6. Evaluation in an international collaborative study. J. Immunol. Meth. 160:147.