Mouse Monoclonal Antibody to PTK6

PTK6 (protein tyrosine kinase 6 BRK or FLJ42088) with 451-amino acid protein (about 52kDa) encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate and low levels in some fetal tissues. And Expressed at low level in some breast tumors but not in normal breast. Also found in melanocytes but not expressed in heart brain placenta lung liver skeletal muscle kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.

2H12B8

Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test. 1. Wilks A. F. Proc. Natl. Acad. Sci. USA 86: 1603-1607. 2. Ottilie S. et al. Oncogene 7: 1625-1630. 3. Lee S. T. et al. Oncogene 8: 3403-3410.