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Mouse Monoclonal antibody to SMAD6

Mouse Monoclonal antibody to SMAD6

Item no.	20-651-487465
Manufacturer	GENWAY
Amount	0,1 ml
Type	Antibody Monoclonal
Clone	5H3
Specific against	Mouse (Murine, Mus musculus)
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	GWB-3C6914
Similar products	20-651-487465
Available
Genway ID:	GWB-3C6914
Description:	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.
Tissue Specificity:	Ubiquitous in various organs with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Isotype:	Mouse IgG1
Clone:	5H3
Immunogen:	Purified recombinant fragment of human SMAD6 expressed in E. Coli. Formulation: Ascitic fluid containing 0. 03% sodium azide.
Application:	Western Bloting: 1/500 - 1/2000. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test. 1. J Biol Chem. 2006 Feb 10; 281(6):3569-76. 2. Nat Immunol. 2006 Oct; 7(10):1057-65. 3. J Med Genet. 2009 May; 46(5):331-7.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,1 ml

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