Antibodies

RAT ANTI MOUSE CD18

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Applications WB, IP
Amount 0.1 mg
Host Rat
ArtNr 20-783-314592
Available
Genway ID:
GWB-54E648
Specificity:
CD18
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
Immunogen:
Membrane glycoproteins of cytotoxic T-cells
Specificity:
Recognises the murine beta 2 integrin (CD18). CD18 is a 95KD cell surface glycoprotein that forms heterodimers with the integrin subunit alpha L (CD11a) alpha M (CD11b) or alpha X (CD11c) to produce integrins CD11a/CD18 CD11b/CD18 and CD11c/CD18 respectively. CD18 is expressed by all leucocytes and plays an important role in adhesion and signalling in the haematopoietic system. Clone M18/2 has been reported to both inhibit and enhance certain functions of CD18 (please refer to references 2 and 3). Removal of sodium azide is recommended prior to use in functional assays - Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Subunit structureHeterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L alpha-M alpha-X or alpha-D. Interacts with COPS5 and RANBP9 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesBelongs to the integrin beta chain family. Contains 1 VWFA domain. [1] \" Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. \" Inagaki N. Gonoi T. Clement J. P. IV Namba N. Inazawa J. Gonzalez G. Aguilar-Bryan L. Seino S. Bryan J. Science 270:1166-1170(1995) [PubMed: 7502040] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT SER-148. Tissue: Placenta. [2] \" Human chromosome 11 DNA sequence and analysis including novel gene identification. \" Taylor T. D. Noguchi H. Totoki Y. Toyoda A. Kuroki Y. Dewar K. Lloyd C. Itoh T. Takeda T. Kim D. -W. She X. Barlow K. F. Bloom T. Bruford E. Chang J. L. Cuomo C. A. Eichler E. FitzGerald M. G. Jaffe D. B. LaButti K. Nicol R. Park H. -S. Seaman C. Sougnez C. Yang X. Zimmer A. R. Zody M. C. Birren B. W. Nusbaum C. Fujiyama A. Hattori M. Rogers J. Lander E. S. Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] VARIANTS LYS-23 AND VAL-337. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen. [4] \" Molecular basis for Kir6. 2 channel inhibition by adenine nucleotides. \" Ribalet B. John S. A. Weiss J. N. Biophys. J. 84:266-276(2003) [PubMed: 12524280] [Abstract]Cited for: MOLECULAR BASIS OF ATP SENSITIVITY. [5] \" Congenital hyperinsulinism: molecular basis of a heterogeneous disease. \" Meissner T. Beinbrech B. Mayatepek E. Hum. Mutat. 13:351-361(1999) [PubMed: 10338089] [Abstract]Cited for: REVIEW ON VARIANTS. [6] \" Homozygosity mapping to chromosome 11p of the gene for familial persistent hyperinsulinemic hypoglycemia of infancy. \" Thomas P. M. Cote G. J. Hallman D. M. Mathew P. M. Am. J. Hum. Genet. 56:416-421(1995) [PubMed: 7847376] [Abstract]Cited for: VARIANT HHF2 PRO-147. [7] \" Mutation of the pancreatic islet inward rectifier Kir6. 2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. \" Thomas P. Ye Y. Lightner E. Hum. Mol. Genet. 5:1809-1812(1996) [PubMed: 8923010] [Abstract]Cited for: VARIANT HHF2 PRO-147. [8] \" Sequence variations in the human Kir6. 2 gene a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro. \" Sakura H. Wat N. Horton V. Millns H. Turner R. C. Ashcroft F. M. Diabetologia 39:1233-1236(1996) [PubMed: 8897013] [Abstract]Cited for: VARIANTS NIDDM PRO-355 AND LYS-PRO-380 INS VARIANTS LYS-23; VAL-270; VAL-337 AND CYS-385. [9] \" Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6. 2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM. \" Inoue H. Ferrer J. Warren-Perry M. Zhang Y. Millns H. Turner R. C. Elbein S. C. Hampe C. L. Suarez B. K. Inagaki N. Seino S. Permutt M. A. Diabetes 46:502-507(1997) [PubMed: 9032109] [Abstract]Cited for: VARIANTS LYS-10; LYS-23; VAL-270 AND VAL-337. [10] \" Molecular biology of adenosine triphosphate-sensitive potassium channels. \" Aguilar-Bryan L. Bryan J. Endocr. Rev. 20:101-135(1999) [PubMed: 10204114] [Abstract]Cited for: VARIANT HHF2 ARG-91.
Amount: 0.1 mg
Available: In stock
Listprice: €242.60
Discount: -10.0%
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