RAT ANTI MOUSE CD273:FITC

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314609
Available
Genway ID:
GWB-26B941
Specificity:
CD273
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
B7-DC transfected RAW264. 7 cells.
Specificity:
Recognises mouse CD273 a 42kD member of the B7 family otherwise known as B7-dendritic cell (B7-DC) or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs) and DCs and macrophages that have been stimulated with interferon gamma GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279) along with another B7 family member B7-H1 (CD279). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. Antibodies produced by clone TY25 are reported to block the binding of CD273 (B7-DC) to it\' s receptor (1). Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROL:FITC
Function:
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Ref. 1Ref. 3Ref. 4Subunit structureInteracts with PDCD1. Ref. 1Subcellular locationCell membrane; Single-pass type I membrane protein By similarity. Tissue specificityExpressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta liver and weakly expressed in heart spleen lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin. Ref. 1Ref. 3Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Kishi M et al (2005) Mammalian SAD kinases are required for neuronal polarization. Science 307:929-322. Lu R et al. (2004) Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J. Biol. Chem. 2004; 279:31164-70. [1] \" LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily including MARK/PAR-1. \" Lizcano J. M. Goeransson O. Toth R. Deak M. Morrice N. A. Boudeau J. Hawley S. A. Udd L. Maekelae T. P. Hardie D. G. Alessi D. R. EMBO J. 23:833-843(2004) [PubMed: 14976552] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION ENZYME REGULATION PHOSPHORYLATION AT THR-205 MUTAGENESIS OF THR-205. [2] Inoue E. Ohtsuka T. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [3] \" Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. \" Lu R. Niida H. Nakanishi M. J. Biol. Chem. 279:31164-31170(2004) [PubMed: 15150265] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) FUNCTION SUBCELLULAR LOCATION TISSUE SPECIFICITY MUTAGENESIS OF LYS-75. Tissue: Testis. [4] She X. Y. Yu L. Guo J. H. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain. [5] \" The full-ORF clone resource of the German cDNA consortium. \" Bechtel S. Rosenfelder H. Duda A. Schmidt C. P. Ernst U. Wellenreuther R. Mehrle A. Schuster C. Bahr A. Bloecker H. Heubner D. Hoerlein A. Michel G. Wedler H. Koehrer K. Ottenwaelder B. Poustka A. Wiemann S. Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-794. Tissue: Brain. [6] \" Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. \" Nagase T. Nakayama M. Nakajima D. Kikuno R. Ohara O. DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-794. Tissue: Brain. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-794. Tissue: Lymph. [8] \" Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. \" Gauci S. Helbig A. O. Slijper M. Krijgsveld J. Heck A. J. Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 MASS SPECTROMETRY. Tissue: Embryonic kidney. [9] \" Large-scale proteomics analysis of the human kinome. \" Oppermann F. S. Gnad F. Olsen J. V. Hornberger R. Greff Z. Keri G. Mann M. Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-463 AND SER-524 MASS SPECTROMETRY. [10] \" Patterns of somatic mutation in human cancer genomes. \" Greenman C. Stephens P. Smith R. Dalgliesh G. L. Hunter C. Bignell G. Davies H. Teague J. Butler A. Stevens C. Edkins S. O\' Meara S. Vastrik I. Schmidt E. E. Avis T. Barthorpe S. Bhamra G. Buck G. Choudhury B. Clements J. Cole J. Dicks E. Forbes S. Gray K. Halliday K. Harrison R. Hills K. Hinton J. Jenkinson A. Jones D. Menzies A. Mironenko T. Perry J. Raine K. Richardson D. Shepherd R. Small A. Tofts C. Varian J. Webb T. West S. Widaa S. Yates A. Cahill D. P. Louis D. N. Goldstraw P. Nicholson A. G. Brasseur F. Looijenga L. Weber B. L. Chiew Y. -E. DeFazio A. Greaves M. F. Green A. R. Campbell P. Birney E. Easton . F. Chenevix-Trench G. Tan M. -H. Khoo S. K. Teh B. T. Yuen S. T. Leung S. Y. Wooster R. Futreal P. A. Stratton M. R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-319; ILE-335; GLU-407; ASN-547; SER-765 AND ALA-780.
Amount: 0.1 mg
Available: In stock
Listprice: €242.60
Discount: -10.0%
Price: €218.34
You save: €24.26
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